JC-10
| Code | Size | Price |
|---|
| CDX-T0103-M001 | 1 mg | £108.00 |
Quantity:
| CDX-T0103-M005 | 5 mg | £255.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
+4°C
Documents
Further Information
Appearance:
Deep blue, violet crystals.
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Keep cool and dry.Protect from light and moisture.
Long Description:
Chemical. CAS: n.a. Synthetic Derivative of JC-1 useful for determining mitochondrial membrane potential by flow cytometry, fluorescence microscopy and in microplate-based fluorescent assays. Accumulates in mitochondria, selectively generating an orange J-aggregate emission profile (570 nm) in healthy cells. Upon cell injury, as membrane potential decreases, JC-10 monomers are generated, resulting in a shift to green emission (520 nm). Shows improved solubility compared to JC-1 in aqueous media and an ability to detect subtler changes in mitochondrial membrane potential loss. Spectral data: lambdaex 510 nm| lambdaem 525.
Package Type:
Vial
Product Description:
Derivative of JC-1 useful for determining mitochondrial membrane potential by flow cytometry, fluorescence microscopy and in microplate-based fluorescent assays. Accumulates in mitochondria, selectively generating an orange J-aggregate emission profile (570 nm) in healthy cells. Upon cell injury, as membrane potential decreases, JC-10 monomers are generated, resulting in a shift to green emission (520 nm). Shows improved solubility compared to JC-1 in aqueous media and an ability to detect subtler changes in mitochondrial membrane potential loss. Spectral data: lambdaex 510 nm| lambdaem 525.
Purity:
>98% (HPLC)
Solubility Chemicals:
Soluble in DMSO or water.
Source / Host:
Synthetic
Transportation:
Non-hazardous
UNSPSC Category:
Fluorescent Reagents
UNSPSC Number:
41105331
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
(1) L. Donaghy, et al.; PLoS One 7, e46594 (2012) | (2) C.C. Chen, et al.; Drug Des. Dev. Ther. 8, 459 (2014) | (3) S. Yokokura, et al.; BMC Cancer 26, 882 (2014) | (4) C. Filippi, et al.; Nanotoxicology 9, 126 (2015)
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