anti-Betatrophin (human) pAb (IN108)
| Code | Size | Price |
|---|
| AG-25B-0033-C100 | 100 ug | £160.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Shipping:
-20°C
Storage:
-20°C
Further Information
Alternate Names/Synonyms:
Angiopoietin-like Protein 8; ANGPTL8; Lipasin; Refeeding-induced Fat and Liver Protein; RIFL; Betatrophin
Concentration:
1mg/ml
EClass:
32160000
Form (Short):
liquid
Formulation:
Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Handling Advice:
After opening, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.
Immunogen:
Recombinant human ANGPTL8 (betatrophin).
Long Description:
Polyclonal Antibody. Recognizes human ANGPTL8 [Betatrophin]. Source: Rabbit. Applications: ELISA, WB. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. ANGPTL8 (Angiopoietin-like protein 8; RIFL; Lipasin; Betatrophin) is a newly discovered secreted protein of 198 aa that was proposed to promote beta cell proliferation and improve glucose tolerance in mice. ANGPTL8 may also function in inhibition of lipase activity and on serum triglyceride regulation. ANGPTL8 is expressed in the liver and in white and brown adipose tissue of mice. In humans, ANGPTL8 is found to be predominantly expressed in the liver. ANGPTL8 levels are reduced by fasting and are elevated upon insulin resistance and during pregnancy. ANGPTL8, according to preliminary data could bind to the macrophage receptor Marco and also to RTN4R, a neuronal receptor. Recently, a study using ANGPTL8 KO mice showed that ANGPTL8 does not play a role in beta cell proliferation nor in glycemic control as previously thought, but regulates plasma triglyceride levels.
Package Type:
Plastic Vial
Product Description:
ANGPTL8 (Angiopoietin-like protein 8; RIFL; Lipasin; Betatrophin) is a newly discovered secreted protein of 198 aa that was proposed to promote beta cell proliferation and improve glucose tolerance in mice. ANGPTL8 may also function in inhibition of lipase activity and on serum triglyceride regulation. ANGPTL8 is expressed in the liver and in white and brown adipose tissue of mice. In humans, ANGPTL8 is found to be predominantly expressed in the liver. ANGPTL8 levels are reduced by fasting and are elevated upon insulin resistance and during pregnancy. ANGPTL8, according to preliminary data could bind to the macrophage receptor Marco and also to RTN4R, a neuronal receptor. Recently, a study using ANGPTL8 KO mice showed that ANGPTL8 does not play a role in beta cell proliferation nor in glycemic control as previously thought, but regulates plasma triglyceride levels.
Source / Host:
Rabbit
Specificity:
Recognizes human betatrophin.
Transportation:
Non-hazardous
UNSPSC Category:
Primary Antibodies
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.
References
Transplantation of betatrophin-expressing adipose-derived mesenchymal stem cells induces beta-cell proliferation in diabetic mice: LL. Sun, et al.; Int. J. Mol. Med. 39, 936 (2017)