CK2 Inhibitor 10
| Code | Size | Price |
|---|
| AG-CR1-3626-M001 | 1 mg | £40.00 |
Quantity:
| AG-CR1-3626-M005 | 5 mg | £95.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Storage:
+4°C (short term), -20°C (long term).
Documents
Further Information
Alternate Names/Synonyms:
CK2-VIII; 4-(2-(4-Methoxybenzamido)thiazol-5-yl)benzoic acid
Appearance:
Off-white to pale yellow solid.
CAS:
1361229-76-6
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Keep cool and dry.
InChi:
InChI=1S/C18H14N2O4S/c1-24-14-8-6-12(7-9-14)16(21)20-18-19-10-15(25-18)11-2-4-13(5-3-11)17(22)23/h2-10H,1H3,(H,22,23)(H,19,20,21)
InChiKey:
UPIVZLFKYMNZDG-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 1361229-76-6. Formula: C18H14N2O4S . 0.5H2O. MW: 354.4 . 9.0. Potent and ATP-competitive inhibitor of casein kinase 2 (IC50 CK2alpha=32nM and IC50 CK2alpha'=46nM). Potently also inhibits DYRK1B and FLT3. Anticancer compound. Exhibits potent cytotoxicity towards lung cancer cells A549, colorectal cancer cells HCT-116 and breast cancer cells MCF-7. Promoted cAMP-induced thermogenesis in white adipocytes. CK2 inhibition ameliorates diet-induced obesity and insulin resistance in mice in vivo by promoting UCP1-dependent thermogenesis.
MDL:
MFCD28127268
Molecular Formula:
C18H14N2O4S . 0.5H2O
Molecular Weight:
354.4 . 9.0
Package Type:
Vial
Product Description:
Potent and ATP-competitive inhibitor of casein kinase 2 (IC50 CK2alpha=32nM and IC50 CK2alpha'=46nM). Potently also inhibits DYRK1B and FLT3. Anticancer compound. Exhibits potent cytotoxicity towards lung cancer cells A549, colorectal cancer cells HCT-116 and breast cancer cells MCF-7. Promoted cAMP-induced thermogenesis in white adipocytes. CK2 inhibition ameliorates diet-induced obesity and insulin resistance in mice in vivo by promoting UCP1-dependent thermogenesis.
Purity:
>98% (HPLC, MS, NMR)
SMILES:
COC1=CC=C(C=C1)C(=O)NC1=NC=C(S1)C1=CC=C(C=C1)C(O)=O
Solubility Chemicals:
Soluble in DMSO. Insoluble in water.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Structure-based design of novel potent protein kinase CK2 (CK2) inhibitors with phenyl-azole scaffolds: Z. Hou, et al.; J. Med. Chem. 55, 2899 (2012) | Phosphoproteomics identifies CK2 as a negative regulator of beige adipocyte thermogenesis and energy expenditure: K. Shinoda, et al.; Cell Metab. 22, 997 (2015)
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