SUSD3 Antibody
| Code | Size | Price |
|---|
| PSI-8475-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-8475-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Storage:
SUSD3 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
Documents
Further Information
Additional Names:
Sushi domain containing 3
Application Note:
SUSD3 antibody can be used for the detection of SUSD3 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunocytochemistry starting at 5 μg/mL.
Antibody validated: Western Blot in human samples and Immunocytochemistry in mouse samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples and Immunocytochemistry in mouse samples. All other applications and species not yet tested.
Background:
Little is known of the function of the sushi domain containing 3 protein (SUSD3), but its expression has been reported in estrogen receptor-alpha (ERalpha)-positive breast tumors with decreased expression reported in aggressive malignant tumors (1,2). Recently, SUSD3 has been found to promote estrogen-dependent cell proliferation and may regulate cell-cell and cell-substrate interactions and migration in breast cancer (3). Furthermore, elevated SUSD3 mRNA levels were observed in aromatase inhibitor-responsive breast tumors, suggesting that it may also serve as a novel predictor of response to endocrine therapy and a potential therapeutic target (3).
Background References:
- Abba MC, Hu Y, Sun H, et al. Gene expression signature of estrogen receptor alpha status in breast cancer. BMC Genomics 2005; 6:37.
- Parris TZ, Danielsson A, Nemes S, et al. Clinical implications of gene dosage and gene expression patterns in diploid breast cancer. Clin. Cancer Res. 2010; 16:3860-74.
- Moy I, Todorovic V, Dubash AD, et al. Estrogen-dependent sushi domain containing 3 regulates cytoskeleton organization and migration in breast cancer cells. Oncogene 2015; 34:323-33.
Buffer:
SUSD3 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
SUSD3 antibody was raised against a 16 amino acid peptide from near the center of human SUSD3.
The immunogen is located within amino acids 120 - 170 of SUSD3.
The immunogen is located within amino acids 120 - 170 of SUSD3.
NCBI Gene ID #:
203328
NCBI Official Name:
Sushi domain containing 3
NCBI Official Symbol:
SUSD3
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 16, 22, 23, 28 kDa
Observed: 23 kDa
Observed: 23 kDa
Protein Accession #:
NP_659443
Protein GI Number:
21450717
Purification:
SUSD3 Antibody is affinity chromatography purified via peptide column.
Research Area:
Cell Cycle,Cancer
SPECIFICITY:
SUSD3 antibody is human and mouse reactive. Multiple isoforms of SUSD3 are known to exist.
Swissprot #:
Q96L08
User NOte:
Optimal dilutions for each application to be determined by the researcher.