13-cis-4-Oxoretinoic acid
| Code | Size | Price |
|---|
| CDX-O0048-M001 | 1 mg | £145.00 |
Quantity:
| CDX-O0048-M005 | 5 mg | £547.00 |
Quantity:
| CDX-O0048-M025 | 25 mg | £2,159.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
+4°C
Documents
Further Information
Alternate Names/Synonyms:
4-Oxoisotretinoin; Ro 22-6595
Appearance:
Dark yellow powder.
CAS:
71748-58-8
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07,GHS08
Handling Advice:
Keep cool and dry.Protect from light and moisture.
Hazards:
H315, H319, H335, H360
InChi:
InChI=1S/C20H26O3/c1-14(7-6-8-15(2)13-19(22)23)9-10-17-16(3)18(21)11-12-20(17,4)5/h6-10,13H,11-12H2,1-5H3,(H,22,23)/b8-6+,10-9+,14-7+,15-13-
InChiKey:
GGCUJPCCTQNTJF-FAOQNJJDSA-N
Long Description:
Chemical. CAS: 71748-58-8. Formula: C20H26O3. MW: 314.42. Synthetic. Mayor active metabolites of 13-cis-retinoic acid (important drug in dermatology and treatment of neuroblastoma) with effects on gene transcription that regulate growth, differentiation and inflammation in normal and neoplastic skin cells. Shown to be as active as 13-cis-retinoic acid against neuroblastoma cell lines. Can be used as reference compound.
MDL:
MFCD00870452
Molecular Formula:
C20H26O3
Molecular Weight:
314.42
Package Type:
Vial
Precautions:
P201, P280, P305, P351, P338, P308, P313, P337, P313
Product Description:
Mayor active metabolites of 13-cis-retinoic acid (important drug in dermatology and treatment of neuroblastoma) with effects on gene transcription that regulate growth, differentiation and inflammation in normal and neoplastic skin cells. Shown to be as active as 13-cis-retinoic acid against neuroblastoma cell lines. Can be used as reference compound.
Purity:
>98% (HPLC)
Signal word:
Danger
SMILES:
CC(C=CC1=C(C)C(=O)CCC1(C)C)=C/C=C/C(/C)=CC(O)=O
Solubility Chemicals:
Soluble in acetone, chloroform, ethanol (slightly) or ether.
Source / Host:
Synthetic.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
(1) F.M. Vane & C.J. Bugge; Drug Metab. Dispos. 9, 515 (1981) | (2) J.M. Baron, et al.; J. Invest. Derm. 125, 143 (2005) | (3) S.E. Rowbotham, et al.; DMD 38, 1211 (2010) | (4) P. Sonawane, et al.; Br. J. Pharmacol. 171, 5330 (2014)