8-Methoxypsoralen
| Code | Size | Price |
|---|
| CDX-M0156-G005 | 5 g | £169.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
+4°C
Documents
Further Information
Alternate Names/Synonyms:
8-MP; 8-MOP; 8-Methoxy-6,7-furanocoumarin; 9-Methoxyfuro[3,2-g][1]benzopyran-7-one; 5-Demethoxyisoimpinellin; Ammoidin; Methoxsalen; Xanthotoxin
Appearance:
White to yellow powder.
CAS:
298-81-7
EClass:
32160000
Form (Short):
solid
GHS Symbol:
GHS07,GHS08
Handling Advice:
Keep cool and dry.Protect from light and moisture.
Hazards:
H302, H317, H350
InChi:
InChI=1S/C12H8O4/c1-14-12-10-8(4-5-15-10)6-7-2-3-9(13)16-11(7)12/h2-6H,1H3
InChiKey:
QXKHYNVANLEOEG-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 298-81-7. Formula: C12H8O4. MW: 216.19. Synthetic. Methoxsalen (8-Methoxypsoralen) is a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450). Has more potency than 5-MOP, 5-OH-P, DH-8-MOP and psoralen in inhibiting CYP2B1 (cytochrome P-450 2B1). Completely inhibits the metabolism of nicotine in vitro. Inhibits the metabolism of caffeine. Methoxsalen is a drug with photoactivating properties used to treat psoriasis, eczema, vitiligo and some cutaneous lymphomas in conjunction with exposing the skin to UVA light. Upon photoactivation, ultraviolet A (UVA) irradiation induces monoadducts and interstrand cross-links in DNA and therefore can be used to study DNA repair and recombination mechanisms.
MDL:
MFCD00005009
Molecular Formula:
C12H8O4
Molecular Weight:
216.19
Package Type:
Vial
Precautions:
P261, P280, P301, P312, P330, P302, P352, P405
Product Description:
Methoxsalen (8-Methoxypsoralen) is a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450). Has more potency than 5-MOP, 5-OH-P, DH-8-MOP and psoralen in inhibiting CYP2B1 (cytochrome P-450 2B1). Completely inhibits the metabolism of nicotine in vitro. Inhibits the metabolism of caffeine. Methoxsalen is a drug with photoactivating properties used to treat psoriasis, eczema, vitiligo and some cutaneous lymphomas in conjunction with exposing the skin to UVA light. Upon photoactivation, ultraviolet A (UVA) irradiation induces monoadducts and interstrand cross-links in DNA and therefore can be used to study DNA repair and recombination mechanisms.
Purity:
>95% (HPLC)
Signal Word:
Danger
SMILES:
COC1=C2OC=CC2=CC2=C1OC(=O)C=C2
Solubility Chemicals:
Soluble in acetic acid or water (slightly).
Source / Host:
Synthetic.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
(1) A. Lassus, et al.; Photodermatol. 1, 170 (1984) | (2) F.A. de Wolff, et al.; Clin. Pharmacokinet. 11, 62 (1986) | (3) G. Labbe, et al.; Biochem. Pharmacol. 36, 907 (1987) | (4) D.C. Mays, et al.; Clin. Pharmacol. Ther. 42, 621 (1987) | (5) G. Labbe, et al.; J. Pharmacol. Exp. Ther. 250, 1034 (1989) | (6) H.G. Jeong, et al.; BBRC 208, 1124 (1995) | (7) J.H. Gwang; Cancer Lett. 109, 115 (1996) | (8) M. Farhadi, et al.; Cell J. 15, 348 (2014) | (9) D. Bagdas, et al.; Neuropharmacol. 85, 67 (2014)