CTPB
| Code | Size | Price |
|---|
| AG-CR1-0141-M001 | 1 mg | £50.00 |
Quantity:
| AG-CR1-0141-M005 | 5 mg | £130.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Storage:
Short term: +4°C, Long Term: -20°C
Documents
Further Information
Alternate Names/Synonyms:
N-(4-Chloro-3-trifluoromethyl-phenyl)-2-ethoxy-6-pentadecyl-benzamide
Appearance:
White to off-white crystalline solid.
CAS:
586976-24-1
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Keep cool and dry.Protect from light.
InChi:
InChI=1S/C31H43ClF3NO2/c1-3-5-6-7-8-9-10-11-12-13-14-15-16-18-24-19-17-20-28(38-4-2)29(24)30(37)36-25-21-22-27(32)26(23-25)31(33,34)35/h17,19-23H,3-16,18H2,1-2H3,(H,36,37)
InChiKey:
OYBMVMAXKOGYDC-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 586976-24-1. Formula: C31H43ClF3NO2. MW: 554.1. Potent activator of p300 HAT (histone acetyltransferase) activity, which has an important role in regulation of gene expression. Does not show PCAF (p300/CBP-associated factor) HAT activities. Membrane-impermeable that requires a carrier to pass the membrane barrier of cells.
MDL:
MFCD08702707
Molecular Formula:
C31H43ClF3NO2
Molecular Weight:
554.1
Package Type:
Vial
Product Description:
Potent activator of p300 HAT (histone acetyltransferase) activity, which has an important role in regulation of gene expression. Does not show PCAF (p300/CBP-associated factor) HAT activities. Membrane-impermeable that requires a carrier to pass the membrane barrier of cells.
Purity:
>98% (HPLC)
SMILES:
CCCCCCCCCCCCCCCC1=C(C(=O)NC2=CC(=C(Cl)C=C2)C(F)(F)F)C(OCC)=CC=C1
Solubility Chemicals:
Soluble in DMSO and other organic solvents.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark.
References
Small molecule modulators of histone acetyltransferase p300: K. Balasubramanyam, et al.; J. Biol. Chem. 278, 19134 (2003) | Activation of p300 histone acetyltransferase by small molecules altering enzyme structure: probed by surface-enhanced Raman spectroscopy: K. Mantelingu, et al.; J. Phys. Chem. B. 111, 4527 (2007) | Synthesis of benzamides related to anacardic acid and their histone acetyltransferase (HAT) inhibitory activities: J.A. Souto, et al.; ChemMedChem 3, 1435 (2008) | Intrinsically fluorescent carbon nanospheres as a nuclear targeting vector: delivery of membrane-impermeable molecule to modulate gene expression in vivo: B.R. Selvi, et al.; Nano Lett. 8, 3182 (2008) | Exploring the binding affinities of p300 enzyme activators CTPB and CTB using docking method: B. Devipriya, et al.; Indian J. Biochem. Biophys. 47, 364 (2010) | Charge density distribution and the electrostatic moments of CTPB in the active site of p300 enzyme: a DFT and charge density study: B. Devipriya & P. Kumaradhas; J. Theor. Biol. 335, 119 (2013) | Histone hypoacetylation contributes to neurotoxicity induced by chronic nickel exposure in vivo and in vitro: C. Zhou, et al.; Sci. Total Environ. 783, 147014 (2021)
Related Products
| Product Name | Product Code | Supplier | C646 | AG-CR1-3508 | AdipoGen Life Sciences | Summary Details | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|