MMG-0358
| Code | Size | Price |
|---|
| AG-CR1-3630-M001 | 1 mg | £75.00 |
Quantity:
| AG-CR1-3630-M005 | 5 mg | £270.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Storage:
Short term: +4°C, Long Term: -20°C
Documents
Further Information
Alternate Names/Synonyms:
4-Chloro-2-(1H-1,2,3-triazol-5-yl)phenol
Appearance:
White solid.
CAS:
1378976-02-3
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
Keep cool and dry.Protect from light.
Hazards:
H319
InChi:
InChI=1S/C8H6ClN3O/c9-5-1-2-8(13)6(3-5)7-4-10-12-11-7/h1-4,13H,(H,10,11,12)
InChiKey:
NBDFMTBYKCBTSW-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 1378976-02-3. Formula: C8H6ClN3O. MW: 195.6. Potent triazole IDO1 (indoleamine 2,3-dioxygenase 1) inhibitor. Has IC50 values of 2nM in a cellular assay on mIDO1, 80nM in a cellular assay on hIDO1, 330nM in an enzymatic assay on hIDO1 at pH 6.5 and 71nM in an enzymatic assay on hIDO1 at pH 7.4. Shown to be active in vivo.
MDL:
MFCD24730415
Molecular Formula:
C8H6ClN3O
Molecular Weight:
195.6
Other data:
NOTE: Prepare a 20mM solution in pure anhydrous DMSO. Prior to performing biological experiments we recommend to make dilutions of the stock solution into aqueous buffers (1mM solution of MMG-0358 in a 95% buffer/5% DMSO mixture).
Package Type:
Vial
Precautions:
P280, P305, P351, P338
Product Description:
Potent triazole IDO1 (indoleamine 2,3-dioxygenase 1) inhibitor. Has IC50 values of 2nM in a cellular assay on mIDO1, 80nM in a cellular assay on hIDO1, 330nM in an enzymatic assay on hIDO1 at pH 6.5 and 71nM in an enzymatic assay on hIDO1 at pH 7.4. Shown to be active in vivo.
Purity:
>98% (HPLC)
Signal word:
Warning
SMILES:
OC1=C(C=C(Cl)C=C1)C1=CN=NN1
Solubility Chemicals:
Soluble in DMSO (20mM).
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Rational design of 4-aryl-1,2,3-triazoles for indoleamine 2,3-dioxygenase 1 inhibition: U.F. Roehrig, et al.; J. Med. Chem. 55, 5270 (2012) | Challenges in the Discovery of Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors: U.F. Roehrig, et al.; J. Med. Chem. 58, 9421 (2015) (Review)