NS5B Antibody [5B-12B7]
| Code | Size | Price |
|---|
| PSI-36-097-100ug | 100ug | £657.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG2a
Antibody Clonality: Monoclonal
Antibody Clone: 5B-12B7
Regulatory Status: RUO
Target Species: Kangaroo
Applications:
- Functional Study
- Immunocytochemistry (ICC)
- Immunoprecipitation (IP)
Storage:
Stable for at least 1 year after receipt when stored at -20˚C.
Documents
Further Information
Additional Names:
Nonstructural Protein 5B
Application Note:
Western Blot: (1-2ug/ml) . Optimal conditions must be determined individually for each application.
Background:
The NS3 serine protease, in association with NS4A, is responsible for the cleavages of the Hepatitis C virus protease complexes NS3-NS4A, NS4A-NS4B, NS4B-NS5A and NS5A-NS5B. NS5B is a RNA-dependent RNA polymerase that plays an essential role in the virus replication. Hepatitis C virus protease NS3-NS4A colocalizes with IPS-1/VISA/MAVS/Cardif in the mitochondrial membrane and has been shown to cleave the TLR3 adapter TRIF and Cardif to eliminate the antiviral signaling pathways. NS3-NS4A represents an important target for anti-HCV drugs.
Buffer:
Liquid. In PBS containing 0.02% sodium azide.
Concentration:
1 mg/ml
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Recombinant hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase.
Physical State:
Liquid
Purification:
>95% (SDS-PAGE)
Research Area:
Innate Immunity,Functional Assays
SPECIFICITY:
Recognizes HCV NS5B from HCV genotype 1 (epitope mapped to NS5B aa 139-392). Does not react with genotype 2.
User NOte:
Optimal dilutions for each application to be determined by the researcher.