PARP-10 Antibody [5H11]
| Code | Size | Price |
|---|
| PSI-36-172-1ml | 1ml | £597.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rat
Antibody Isotype: IgG1
Antibody Clonality: Monoclonal
Antibody Clone: 5H11
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunocytochemistry (ICC)
- Immunoprecipitation (IP)
- Western Blot (WB)
Storage:
Stable for at least 1 year after receipt when stored at +4˚C.
Documents
Further Information
Additional Names:
ADP-ribosyltransferase Diphtheria Toxin-like 10; Poly(ADP-ribose) Polymerase-10
Application Note:
Immunocytochemistry:(1:50-1:200). Immunoprecipitation:(1:10). Western Blot:(1:50). Optimal conditions must be determined individually for each application.
Background:
PARP-10. PARP-10 mono(ADP-ribosyl)ates (MARylates) NEMO (NF-kappaB essential modulator), which results in reduced NEMO polyubiquitylation and thus decreased NF-kappaB signaling. Overexpression of PARP-10 was shown to lead to apoptosis. PARP-10 knockdown leads to increased cell survival. Additional substrates of PARP-10, such as GSK-3beta were identified and PARP-10-mediated mono(ADP-ribosyl)ation (MARylation) was shown to be involved in regulating multiple processes, including Wnt signaling.
Buffer:
Liquid. Cell culture supernatant containing RPMI, 10% FCS and 0.05% sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Recombinant human PARP-10 [ARTD10] (aa 1-907) fused to a GST-tag.
NCBI Gene ID #:
84875
NCBI Official Name:
poly(ADP-ribose) polymerase family member 10
NCBI Official Symbol:
PARP10
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
116248563
Protein GI Number:
Q53GL7
Research Area:
Apoptosis,Cancer,Innate Immunity,Obesity
SPECIFICITY:
Recognizes human PARP-10 [ARTD10] with an epitope between aa 256-407, containing the glycine rich (G-rich) region.
Swissprot #:
Q53GL7
User NOte:
Optimal dilutions for each application to be determined by the researcher.