Clusterin Antibody
| Code | Size | Price |
|---|
| PSI-36-299-100ug | 100ug | £524.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Storage:
Stable for at least 6 months after receipt when stored at -20˚C.
Documents
Further Information
Additional Names:
TRPM-2; Apolipoprotein J; APO-J; CLI; CLU; SGP-2
Application Note:
ELISA: (direct and indirect: 1:2,000-1:5,000). Western Blot: (1:2,000-1:5,000 using ECL; suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk; suggested incubation time is 1 hour at room temperature). Optimal conditions must be determined individually for each application.
Background:
Clusterin shares homology with the small heat shock protein family of molecular chaperones. The mature secreted form of the protein is a glycosylated, 80-kDa disulfide-linked heterodimer of alpha and beta subunits (produced by internal cleavage). Clusterin is expressed in virtually all tissues and found in all human fluids. It is involved in numerous physiological processes important for carcinogenesis and tumor growth, including apoptotic cell death, cell cycle regulation, DNA repair, cell adhesion, tissue remodeling, lipid transportation, membrane recycling, and immune system regulation. Clusterin also exists as a nuclear protein. The secreted form of Clusterin has extracellular chaperone and anti-apoptotic activities while the nuclear form acts as a proapoptotic factor.
Buffer:
Liquid. 0.2um-filtered solution in PBS, pH 7.4. Contains no preservatives.
Concentration:
1 mg/ml
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Recombinant human clusterin (nuclear form).
NCBI Gene ID #:
1191
NCBI Official Name:
clusterin
NCBI Official Symbol:
CLU
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
42716297
Protein GI Number:
NP_001822
Research Area:
Cancer,Immunology,Innate Immunity,Obesity
SPECIFICITY:
Recognizes human clusterin. Detects a band of ~49kDa by Western blot.
Swissprot #:
P10909
User NOte:
Optimal dilutions for each application to be determined by the researcher.