Nampt Antibody

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ProSci
Product Code: PSI-36-225
Product Group: Primary Antibodies
Supplier: ProSci
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PSI-36-225-100ug100ug£597.00
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Overview

Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
Storage:
Stable for at least 6 months after receipt when stored at -20˚C.

Documents

Further Information

Additional Names:
Pre-B Cell Colony Enhancing Factor 1; PBEF1; Nicotinamide Phosphoribosyltransferase
Application Note:
ELISA: (direct and indirect: 1:2,000-1:5,000). Immunohistochemistry: (frozen sections). Optimal conditions must be determined individually for each application.
Background:
Nicotinamide phosphoribosyltransferase (Nampt; pre-B cell colony-enhancing factor; PBEF; Visfatin) is an 52kDa adipokine secreted by adipose tissue and involved in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). Two forms of Nampt exist, an intracellular form (iNampt) and an extracellular form (eNampt). While the function of iNampt as an essential and rate-limiting NAD+ biosynthetic enzyme is well established, the physiological role of eNampt is still a matter of debate. Nampt has various functions, including the promotion of vascular smooth muscle cell maturation and inhibition of neutrophil apoptosis. It activates insulin receptor and has insulin-mimetic effects, lowering blood glucose and improving insulin sensitivity. The protein is highly expressed in visceral fat and serum levels of the protein correlate with obesity.
Buffer:
Liquid. 0.2um-filtered solution in PBS, pH 7.4. Contains no preservatives.
Concentration:
1 mg/ml
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Synthetic peptide corresponding to aa 40-56 (R40EKKTENSKLRKVKYEE56) of human Nampt (Visfatin/PBEF).
NCBI Gene ID #:
10135
NCBI Official Name:
nicotinamide phosphoribosyltransferase
NCBI Official Symbol:
NAMPT
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
5031977
Protein GI Number:
NP_005737
Research Area:
Cancer,Obesity
SPECIFICITY:
Recognizes human Nampt. Weakly cross-reacts with mouse Nampt. Detects a band of ~54kDa by Western blot.
Swissprot #:
P43490
User NOte:
Optimal dilutions for each application to be determined by the researcher.