NLRP6/NALP6 Antibody [Clint-1]
| Code | Size | Price |
|---|
| PSI-36-159-100ug | 100ug | £729.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG1, kappa
Antibody Clonality: Monoclonal
Antibody Clone: Clint-1
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry (IHC)
- Western Blot (WB)
Storage:
Stable for at least 1 year after receipt when stored at -20˚C.
Documents
Further Information
Additional Names:
NACHT-, LRR and PYD Domains-containing Protein 6; Nod-like Receptor Pyrin Domain-containing Protein 6; NLRP6; Angiotensin II/Vasopressin Receptor; PYRIN-containing APAF1-like Protein 5; NALP6
Application Note:
Western Blot: (1ug/ml). Immunohistochemistry: (frozen sections) (1:500).
Background:
The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor (NLR) family are critical components of the inflammasome that link danger-signals to caspase-1 activation. NLRP6/NALP6 is important for intestinal homeostasis by sensing pathogenic commensal bacteria and activating bactericidal activity of macrophages through secretion of IL-18. NLRP6 suppresses inflammation and carcinogenesis by regulating tissue repair and deletion of NLRP6 gene accelerated colitis-associated tumor growth in mice.
Buffer:
Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Concentration:
1 mg/ml
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Recombinant human NLRP6 (NACHT domain).
NCBI Gene ID #:
171389
NCBI Official Name:
NLR family, pyrin domain containing 6
NCBI Official Symbol:
NLRP6
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
21264320
Protein GI Number:
NP_612202
Purification:
>95% (SDS-PAGE)
Research Area:
Immunology,Innate Immunity,Innate Immunity
SPECIFICITY:
Recognizes human NLRP6.
Swissprot #:
P59044
User NOte:
Optimal dilutions for each application to be determined by the researcher.