ProSci

BTLA Antibody [6F4]

Product Code:
 
PSI-36-160
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rat
Antibody Isotype:
 
IgG1
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
6F4
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Flow Cytometry
  • Functional Study
Storage:
 
Stable for at least 1 year after receipt when stored at -20˚C.
 

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PSI-36-160-100ug100ug£686.00
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Further Information

Additional Names:
B and T Lymphocyte Associated; Lymphotoxin-beta Receptor; Tumor Necrosis Factor Receptor 2 Related Protein; Tumor Necrosis Factor C Receptor; Tumor Necrosis Factor Receptor Superfamily Member 3; TNFRSF3
Application Note:
Immunohistochemistry: (frozen sections).
Background:
B and T lymphocyte associated (BTLA) is an Ig domain superfamily protein with cytoplasmic immunoreceptor tyrosine-based inhibitory motifs. The herpes virus entry mediator (HVEM), a member of the TNF receptor (TNFR) superfamily, can act as a molecular switch that modulates T cell activation by propagating positive signals from the TNF-related ligand LIGHT (TNFR superfamily 14), or inhibitory signals through the Ig superfamily member BTLA. The binding site on HVEM for BTLA is conserved in the orphan TNF receptor UL144, present in human CMV. UL144 binds BTLA, but not LIGHT, and inhibits T cell proliferation, selectively mimicking the inhibitory cosignaling function of HVEM.
Buffer:
Liquid. In PBS containing 10% glycerol.
Concentration:
1 mg/ml
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Ectodomain of human BTLA fused to human IgG Fc.
NCBI Gene ID #:
151888
NCBI Official Name:
B and T lymphocyte associated
NCBI Official Symbol:
BTLA
NCBI Organism:
homo sapiens
Physical State:
Liquid
Protein Accession #:
145580621
Protein GI Number:
NP_861445
Purification:
>95% (SDS-PAGE)
Research Area:
Immunology,Innate Immunity,Functional Assays
SPECIFICITY:
Recognizes human BTLA.
Swissprot #:
Q7Z6A9
User NOte:
Optimal dilutions for each application to be determined by the researcher.