ProSci

MDA5 Antibody [Hely-1]

Product Code:
 
PSI-36-114
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Mouse
Antibody Isotype:
 
IgG1
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
Hely-1
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunoprecipitation (IP)
  • Western Blot (WB)
Storage:
 
Stable for at least 1 year after receipt when stored at -20˚C.
 

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PSI-36-114-100ug100ug£686.00
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Further Information

Additional Names:
Helicard; Melanoma Differentiation-associated Gene 5
Application Note:
Immunoprecipitation: (1:100). Western Blot: (1:1?000).
Background:
RIG-I and MDA5 are highly conserved helicases involved in the innate immune response to virus. RIG-I is a member of the DEAD-box RNA helicases and is activated by cytoplasmic dsRNA and 5?-ppp RNA produced during the viral replication. The protein is characterized by a N-terminal region with two caspase recruitment domains (CARD) and a C-terminal region harboring potential ATP-dependent RNA helicase activity. RIG-1 recruits the CARD adaptor inducing IFN-beta (Cardif) in a CARD-CARD-dependent manner resulting in NF-kappaB and IRF3 activation.
Buffer:
Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Concentration:
1 mg/ml
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Recombinant human MDA5 (aa 78-555).
NCBI Gene ID #:
64135
NCBI Official Name:
interferon induced with helicase C domain 1
NCBI Official Symbol:
IFIH1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
27886568
Protein GI Number:
NP_071451
Purification:
>95% (SDS-PAGE)
Research Area:
Immunology,Innate Immunity
SPECIFICITY:
Recognizes human MDA5.
Swissprot #:
Q9BYX4
User NOte:
Optimal dilutions for each application to be determined by the researcher.