ZAG Antibody [Zagy-1]
| Code | Size | Price |
|---|
| PSI-36-168-100ug | 100ug | £686.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG1
Antibody Clonality: Monoclonal
Antibody Clone: Zagy-1
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Storage:
Stable for at least 1 year after receipt when stored at -20˚C.
Documents
Further Information
Additional Names:
Zn-alpha-2-GP; Zn-alpha-2-Glycoprotein; ZAG; ZA2G; AZGP1; ZNGP1
Application Note:
Flow Cytometry: (1:100). Definition for 1 test: 1ul of labeled antibody in 200ul of Flow Cytometry buffer (see online protocol).
Background:
Zinc-alpha-2-glycoprotein (ZAG), first identified in the 1960s, derives its name from its precipitation from human plasma upon the addition of zinc salts. ZAG has since been found in secretory epithelial cells and in a range of body fluids. ZAG is identical to a lipid mobilizing factor isolated from the urine of patients with cancer cachexia and stimulates lipolysis in in vivo experiments. Due to its expression in and secretion from adipocytes, ZAG is considered an adipokine. Recently the clinical significance of ZAG has been clarified. ZAG expression in adipocytes is inversely related to fat mass, thus it is intimately involved in the maintenance of body weight in mice and humans. Epidemiological studies have uncovered an association between ZAG and plasma cholesterol. The non-synonymous single nucleotide polymorphism rs4215 in ZAG is associated with plasma cholesterol and obesity. Structurally ZAG possesses a class I major histocompatibility complex (MHC) protein fold. It is distinct from other members of this protein family in that it is soluble, rather than being anchored to plasma membranes and it associates with prolactin inducible protein rather than beta2-microglobulin. Similar to peptide antigen-presenting class I MHC molecules, ZAG possesses an open apical groove between its alpha1 and alpha2 domain helices.
Buffer:
Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Concentration:
1 mg/ml
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Recombinant human zinc-alpha-2-glycoprotein.
NCBI Gene ID #:
563
NCBI Official Name:
alpha-2-glycoprotein 1, zinc-binding
NCBI Official Symbol:
AZGP1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
292495049
Protein GI Number:
P25311
Purification:
>95% (SDS-PAGE)
Research Area:
Obesity
SPECIFICITY:
Recognizes human zinc-alpha-2-glycoprotein.
Swissprot #:
P25311
User NOte:
Optimal dilutions for each application to be determined by the researcher.