PIDD Antibody
| Code | Size | Price |
|---|
| PSI-36-329-50ug | 50ug | £488.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Applications:
- Immunohistochemistry (IHC)
- Immunoprecipitation (IP)
- Western Blot (WB)
Storage:
Stable for at least 1 year after receipt when stored at -20˚C.
Documents
Further Information
Additional Names:
p53-induced Protein with a Death Domain; Leucine-rich Repeat and Death Domain-containing Protein; Lrdd
Application Note:
Immunohistochemistry: (paraffin sections). Immunoprecipitation: (1:100). Western Blot: (1:500).
Background:
PIDD promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. It associates with NEMO/IKBKG and RIP1 and enhances sumoylation and ubiquitination of NEMO/IKBKG which is important for activation of the transcription factor NF-kappa-B. It associates with caspase-2 and RAIDD, and induces activation of caspase-2 which is an important regulator in the apoptotic pathways.
Buffer:
Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Concentration:
1 mg/ml
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Recombinant human PIDD (Death Domain: aa 776-910).
NCBI Gene ID #:
55367
NCBI Official Name:
p53-induced death domain protein 1
NCBI Official Symbol:
PIDD1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
116242715
Protein GI Number:
Q9HB75
Research Area:
Apoptosis,Cancer,Innate Immunity
SPECIFICITY:
Recognizes human and the native form of mouse PIDD. Detects bands of ~90kDa (full length protein) and ~50kDa (cleaved protein) by Western blot.
Swissprot #:
Q9HB75
User NOte:
Optimal dilutions for each application to be determined by the researcher.