RIG-I Antibody [Alme-1] (biotin)

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ProSci
Product Code: PSI-36-103
Product Group: Primary Antibodies
Supplier: ProSci
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PSI-36-103-100ug100ug£801.00
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Overview

Host Type: Mouse
Antibody Isotype: IgG1
Antibody Clonality: Monoclonal
Antibody Clone: Alme-1
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
Applications:
  • Immunohistochemistry (IHC)
  • Immunoprecipitation (IP)
  • Western Blot (WB)
Storage:
Stable for at least 1 year after receipt when stored at -20˚C.

Documents

Further Information

Additional Names:
RIG-1; Retinoic Acid-inducible Gene 1 Protein; DEAD-box Protein 58; Probable ATP-dependent RNA Helicase DDX58
Application Note:
Immunohistochemistry: (paraffin sections). Immunoprecipitation: (1:200). Western blot: (1:1,000).
Background:
RIG-I and MDA5 are highly conserved helicases involved in the innate immune response to virus. RIG-I is a member of the DEAD-box RNA helicases and is activated by cytoplasmic dsRNA and 5?-ppp RNA produced during the viral replication. The protein is characterized by a N-terminal region with two caspase recruitment domains (CARD) and a C-terminal region harboring potential ATP-dependent RNA helicase activity. RIG-I recruits the CARD adaptor inducing IFN-beta (Cardif) in a CARD-CARD-dependent manner resulting in NF-kappaB and IRF3 activation.
Buffer:
Liquid. In PBS containing 0.02% sodium azide.
Concentration:
0.5 mg/ml
Conjugate:
Biotin
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Recombinant human RIG-I (aa 201-713).
NCBI Gene ID #:
23586
NCBI Official Name:
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
NCBI Official Symbol:
DDX58
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
81170421
Protein GI Number:
O95786
Purification:
>95% (SDS-PAGE)
Research Area:
Immunology,Innate Immunity
SPECIFICITY:
Recognizes human and mouse RIG-I.
Swissprot #:
O95786
User NOte:
Optimal dilutions for each application to be determined by the researcher.