Caveolin-1 Antibody

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ProSci
Product Code: PSI-8219
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-8219-0.02mg0.02mg£150.00
Quantity:
PSI-8219-0.1mg0.1mg£449.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Storage:
Caveolin-1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Images

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Western blot analysis of Caveolin-1 in human lung tissue lysate with Caveolin-1 antibody at (A) 1 and (B) 2 μg/mL.
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Western blot analysis of Caveolin-1 in human lung tissue lysate with Caveolin-1 antibody at (A) 1 and (B) 2 μg/mL.

Documents

Further Information

Additional Names:
Caveolin-1 Antibody: Caveolin-1, BSCL3, CGL3, LCCNS, MSTP085, PPH3, VIP21
Application Note:
Caveolin-1 antibody can be used for detection of Caveolin-1 by Western blot at 1 - 2 μg/ml.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Background:
Caveolin-1 Antibody: Caveolin-1 is a scaffolding protein that is the main component of the caveolae plasma membranes found in most cell types (1). The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression (2). The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade (3). Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy (4).
Background References:
  • Glenney JR Jr. The sequence of human caveolin reveals identity with VIP21, a component of transport vesicles. FEBS Lett. 1992; 314:45-8.
  • Wary KK, Mariotti A, Zurzolo C, et al. A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth. Cell 1998; 94:625-34.
  • Capozza F, Williams TM, Schubert W, et al. Absence of caveolin-1 sensitizes mouse skin to carcinogen-induced epidermal hyperplasia and tumor formation. Am. J. Pathol. 2003; 162:2029-39.
  • Kim CA, Delepine M, Boutet E, et al. Association of a homozygous nonsense caveolin-1 mutation with Berardinelli-Seip congenital lipodystrophy. J. Clin. Endocrinol. Metab. 2008; 93:1129-34.
Buffer:
Caveolin-1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Rabbit: (100%), Horse: (100%), Sheep: (100%), Bovine: (100%), Pig: (100%), Chicken: (88%)
Immunogen:
Caveolin-1 antibody was raised against a peptide corresponding to 18 amino acids near the amino terminus of human Caveolin-1.
NCBI Gene ID #:
857
NCBI Official Name:
caveolin 1
NCBI Official Symbol:
CAV1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 20 kDa

Observed: 21 kDa
Protein Accession #:
NP_001744
Protein GI Number:
15451856
Purification:
Caveolin-1 Antibody is affinity chromatography purified via peptide column.
Research Area:
Signal Transduction,Cancer,Cell Cycle
SPECIFICITY:
At least two isoforms of Caveolin-1 are known to exist; this antibody will detect only the largest isoform.
Swissprot #:
Q03135
User NOte:
Optimal dilutions for each application to be determined by the researcher.