Lipoma Preferred Partner Antibody
| Code | Size | Price |
|---|
| PSI-36-343-50ug | 50ug | £801.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Porcine (pig)
- Rat
Applications:
- Immunocytochemistry (ICC)
- Immunoprecipitation (IP)
- Western Blot (WB)
Storage:
Stable for at least 1 year after receipt when stored at -20˚C.
Documents
Further Information
Additional Names:
LPP; LIM Domain-containing Preferred Translocation Partner in Lipoma
Application Note:
Immunocytochemistry: (1:500). Immunohistochemistry: (1:500). Western Blot: (1:1,000) . Optimal conditions must be determined individually for each application.
Background:
Lipoma preferred partner (LPP) is encoded by the preferred fusion partner gene of the high mobility group protein HMGI-C. LPP is frequently affected by chromosomal translocations in a major group of soft tissue lipomas, as well as in a parosteal lipoma and in pulmonary chondroid hamartomas. The resulting fusion proteins comprise three DNA binding domains of HMGI-C fused to two or three C-terminal LIM domains of LPP and a reciprocal product, respectively. Expression of a HMGI-C/LPP fusion protein causes malignant transformation of fibroblasts. Similar to its relatives zyxin and TRIP (thyroid receptor interacting protein 6) / ZRP-1 (zyxin-related protein 1), LPP consists of a N-terminal proline-rich domain followed by three C-terminal LIM domains (double zinc finger structures that are involved in protein-protein interactions). Like the cytoskeletal protein zyxin, LPP localizes to focal adhesions and cell-cell adherens junctions. LPP harbors a nuclear export signal and displays transcriptional activation capacity.
Buffer:
Liquid. In PBS containing 0.01% sodium azide.
Concentration:
500 ug/ml
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Recombinant human lipoma preferred partner (LPP) (aa 1-109).
NCBI Gene ID #:
4026
NCBI Official Name:
LIM domain containing preferred translocation partner in lipoma
NCBI Official Symbol:
LPP
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
264681524
Protein GI Number:
NP_001161143.1
Purification:
Antigen affinity purified.
Research Area:
Apoptosis,Cancer,Immunology
SPECIFICITY:
Recognizes human, rat and pig LPP.
Swissprot #:
Q93052
User NOte:
Optimal dilutions for each application to be determined by the researcher.