IL-1alpha Antibody [Bamboo-2]
| Code | Size | Price |
|---|
| PSI-36-165-100ug | 100ug | £657.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG1, kappa
Antibody Clonality: Monoclonal
Antibody Clone: Bamboo-2
Regulatory Status: RUO
Target Species: Mouse
Application: Enzyme-Linked Immunosorbent Assay (ELISA)
Storage:
Stable for at least 1 year after receipt when stored at -20˚C.
Documents
Further Information
Additional Names:
Interleukin-1alpha
Application Note:
ELISA: (as a detection antibody).
Background:
The most prominent members of the interleukin-1 (IL-1) superfamily are IL-1alpha and IL-1beta. They lack a signal peptide and are secreted by an unconventional, endoplasmic reticulum-Golgi-independent mechanism. IL-1alpha was reported to be more widely and constitutively expressed and has intracellular functions, but also acts locally in a membrane-bound form by activating IL-1R1. Additionally, passive release of IL-1alpha upon cell death can trigger a sterile inflammatory response to dying cells. The cleavage of IL-1alpha is not mediated by caspase-1 and is not required for binding to IL-1R1. Recently it has been observed that all activators of the inflammasome NLRP3/NALP3 induce the simultaneous secretion of IL-1alpha and IL-1beta. Although most activators fully rely on the inflammasome for IL-1alpha secretion, some induce the processing and secretion of IL-1alpha in an inflammasome-independent manner.
Buffer:
Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Concentration:
1 mg/ml
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Recombinant mouse mature IL-1alpha.
NCBI Gene ID #:
16175
NCBI Official Name:
interleukin 1 alpha
NCBI Official Symbol:
Il1a
NCBI Organism:
Mus musculus
Physical State:
Liquid
Protein Accession #:
124298
Protein GI Number:
P01582
Purification:
>95% (SDS-PAGE)
Research Area:
Apoptosis,Immunology,Innate Immunity
SPECIFICITY:
Recognizes mouse IL-1alpha.
Swissprot #:
P01582
User NOte:
Optimal dilutions for each application to be determined by the researcher.