NAIP1/2/5 Antibody [Naipa-1]
| Code | Size | Price |
|---|
| PSI-36-158-100ug | 100ug | £729.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG2b, kappa
Antibody Clonality: Monoclonal
Antibody Clone: Naipa-1
Regulatory Status: RUO
Target Species: Mouse
Application: Western Blot (WB)
Storage:
Stable for at least 1 year after receipt when stored at -20˚C.
Documents
Further Information
Additional Names:
Neuronal Apoptosis Inhibitory Protein 1, 2, 5; Baculoviral IAP Repeat-containing Protein 1a, 1b, 1e; Birc 1a, 1b, 1e
Application Note:
Western Blot: (1ug/ml).
Background:
The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor (NLR) family are critical components of the inflammasome that link danger-signals to caspase-1 activation. The NLR member IPAF/NLRC4 senses bacterial flagellin and a conserved type III secretion system (TTSS) rod component. A member of the NLR family, NAIP5 directly and specifically interacts with flagellin, triggers a physical NAIP5-NLRC4 association leading to NLRC4 activation. The related NAIP2 functions analogously to NAIP5, serving as a specific inflammasome receptor for TTSS rod proteins such as Salmonella PrgJ and Burkholderia BsaK.
Buffer:
Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Concentration:
1 mg/ml
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Recombinant mouse NAIP5 (BIR2 domain/aa 159-227).
NCBI Gene ID #:
17951
NCBI Official Name:
NLR family, apoptosis inhibitory protein 5
NCBI Official Symbol:
Naip5
NCBI Organism:
Mus musculus
Physical State:
Liquid
Protein Accession #:
12643317
Protein GI Number:
Q9R016
Purification:
>95% (SDS-PAGE)
Research Area:
Immunology,Innate Immunity,Innate Immunity
SPECIFICITY:
Recognizes mouse NAIP1, 2 and 5. Not tested on mouse NAIP6 and mouse NAIP7 but should also work due to high homology in the BIR2 domain.
Swissprot #:
Q9R016
User NOte:
Optimal dilutions for each application to be determined by the researcher.