LTbetaR Antibody [3C8]
| Code | Size | Price |
|---|
| PSI-36-153-100ug | 100ug | £686.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rat
Antibody Isotype: IgG1, kappa
Antibody Clonality: Monoclonal
Antibody Clone: 3C8
Regulatory Status: RUO
Target Species: Mouse
Application: Functional Study
Storage:
Stable for at least 1 year after receipt when stored at -20˚C.
Documents
Further Information
Additional Names:
Lymphotoxin-beta Receptor; Tumor Necrosis Factor Receptor 2 Related Protein; Tumor Necrosis Factor C Receptor; Tumor Necrosis Factor Receptor Superfamily Member 3; TNFRSF3
Application Note:
Functional Application: Agonist inducing BAFF, chemokines and integrins in vitro and in vivo.
Background:
The LTbetaR activates two different NF-kappaB pathways that lead to distinct patterns of gene induction, including selected chemokines and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTbetaR activates the classical NF-kappaB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1beta. However, LTbetaR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.
Buffer:
Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Concentration:
1 mg/ml
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Recombinant mouse LTbetaR (cysteine-rich region/aa 31-221).
NCBI Gene ID #:
17000
NCBI Official Name:
lymphotoxin B receptor
NCBI Official Symbol:
Ltbr
NCBI Organism:
Mus musculus
Physical State:
Liquid
Protein Accession #:
1729988
Protein GI Number:
P50284
Purification:
>95% (SDS-PAGE)
Research Area:
Immunology,Innate Immunity,Functional Assays
SPECIFICITY:
Recognizes mouse LTbetaR.
Swissprot #:
P50284
User NOte:
Optimal dilutions for each application to be determined by the researcher.