Zmp1 M. tuberculosis Recombinant Protein
| Code | Size | Price |
|---|
| PSI-90-361-50ug | 50ug | £782.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Dry ice
Storage:
Stable for at least 6 months after receipt when stored at -80˚C.
Documents
Further Information
Additional Names:
Zinc Metalloprotease 1, Endopeptidase, Rv0198c
Application Note:
This recombinant proteins is for research use only.
Background:
M13 endopeptidases are single-pass, transmembrane zinc-metallopeptidases responsible in human for the regulation of the biological activity of many hormones and peptides and are involved in many important processes such as blood pressure regulation (Neprilysin or NEP1), cardiovascular development (Endothelin Converting Enzyme-1 or ECE-12), prevention of haemolytic reaction (KELL) and phosphate homeostasis (PHEX). Zmp1 is a soluble enzyme member of the M13 endopeptidases family that plays a key role in Mycobacterium tuberculosis pathogenicity with a still unknown mechanism. Recently, it was shown to suppress inflammasome activation by inhibiting caspase-1 activation, thus preventing processing of pro-IL-1beta into IL-1beta and the consequent phagosome maturation.
Biological Activity:
~0.5U/mg protein. Active towards the generic fluorogenic substrate for matrix metalloproteinases MMP2/MMP7 (Lit. 1).
Buffer:
In 10mM TRIS-HCl, pH 8.0.
Concentration:
0.5mg/ml (Lot specific)
Fusion Tag:
His Tag
NCBI Gene ID #:
1064981
NCBI Official Name:
peptidase
NCBI Official Symbol:
TW781
NCBI Organism:
Tropheryma whipplei TW08/27?
Physical State:
Liquid
Protein Accession #:
O53649
Protein GI Number:
81669492
Purity:
>98% (SDS-PAGE)
Recombinant Protein Sequence:
Thr32-Gly402
Source:
E. coli
Swissprot #:
O88324