POP1 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-90-303-10ug | 10ug | £433.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Storage:
Stable for at least 6 months after receipt when stored at -20˚C.
Documents
Further Information
Additional Names:
Pyrin Domain-containing Protein 1, PAAD-only Protein 1, Pyrin-only Protein 1, PYC1
Application Note:
This recombinant proteins is for research use only.
Background:
The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor family (NLRs), including NLRP3/NALP3, are critical components of the inflammasome that link danger-signals to caspase-1 activation. Defects in NLRP3 are the cause of familial cold autoinflammatory syndrome type 1 (FCAS1), Muckle-Wells syndrome (MWS) and of chronic infantile neurologic cutaneous and articular syndrome (CINCA). Pyrin domain-containing protein 1 (POP1) interacts with the protein Asc (Pycard) and modulates the interaction of Asc to NLR proteins.
Buffer:
Contains PBS. Reconstitute with 100 μl sterile water.
Concentration:
0.1mg/ml after reconstitution.
Fusion Tag:
GST tag
NCBI Gene ID #:
260434
NCBI Official Name:
PYD (pyrin domain) containing 1
NCBI Official Symbol:
PYDC1
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
Q8WXC3
Protein GI Number:
74730989
Purity:
>95% (SDS-PAGE)
Recombinant Protein Sequence:
Thr32-Gly402
Source:
E. coli
Swissprot #:
P09038