Kynurenine Aminotransferase II Recombinant Protein
| Code | Size | Price |
|---|
| PSI-90-360-50ug | 50ug | £782.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Shipping:
Dry ice
Storage:
Stable for at least 6 months after receipt when stored at -80˚C.
Documents
Further Information
Additional Names:
hKAT II, KAT2, alpha-Aminoadipate Aminotransferase (Mitochondrial), AADAT, EC 2.6.1.7
Application Note:
This recombinant proteins is for research use only.
Background:
Kynurenine aminotransferases (KATs) are pyridoxal-5?-phosphate-dependent enzymes that catalyze the conversion of L-kynurenine into kynurenic acid, a neuroactive metabolite whose unbalancing is associated with a number of brain disorders. Biochemical and structural investigations revealed that L-kynurenine (L-KYN) recognition by hKAT II is achieved by exploiting structural features that are peculiar of this isoform, thus offering the possibility to select/design inhibitor molecules specifically targeting hKAT II to be used as modulators of kynurenic acid synthesis in the CNS. hKAT II is one of the aminotransferases involved in the pyridoxal 5'-phosphate (PLP)-dependent irreversible transamination of L-kynurenine (L-KYN) to kynurenic acid (KYNA) in the central nervous system. When assayed in vitro the protein also displays beta-elimination activity.
Buffer:
In 50 mM phosphate buffer pH 8.0, containing 50mM sodium chloride and 40uM pyridoxal 5'-phosphate (PLP).
Concentration:
0.5mg/ml (Lot specific)
Fusion Tag:
His Tag
NCBI Gene ID #:
51166
NCBI Official Name:
aminoadipate aminotransferase
NCBI Official Symbol:
AADAT
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_872603
Protein GI Number:
33469970
Purity:
>97% (SDS-PAGE)
Recombinant Protein Sequence:
Thr32-Gly402
Source:
E. coli
Swissprot #:
Q01151