NAPRTase Recombinant Protein
| Code | Size | Price |
|---|
| PSI-90-363-50ug | 50ug | £782.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Shipping:
Dry ice
Storage:
Stable for at least 6 months after receipt when stored at -80˚C.
Documents
Further Information
Additional Names:
Nicotinate Phosphoribosyltransferase, FHA-HIT-interacting Protein, FHIP, EC 2.4.2.11
Application Note:
This recombinant proteins is for research use only.
Background:
Human nicotinate phosphoribosyltransferase (NAPRTase) is localized in the cytoplasm and is involved in biological processes such as NAD biosynthetic and metabolic processes, nicotinamide metabolic process, nicotinate nucleotide salvage, response to oxidative stress and water-soluble vitamin metabolic process. It functions by catalyzing the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) and is essential for NA to increase cellular NAD levels and prevent oxidative stress of the cells. It is a crucial factor in the NAD+ biosynthesis pathway. Catalytic activity: Beta-nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate.
Biological Activity:
~0.27 U/mg protein. One unit is defined as the amount of enzyme that synthesizes 1umol nicotinic acid mononucleotide (NaMN) per min.
Buffer:
In 50mM HEPES/KOH pH 7.5 containing 300mM potassium chloride and 10mM DTT.
Concentration:
0.5mg/ml (Lot specific)
Fusion Tag:
His Tag
NCBI Gene ID #:
93100
NCBI Official Name:
nicotinate phosphoribosyltransferase
NCBI Official Symbol:
NAPRT
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
Q6XQN6
Protein GI Number:
166221824
Purity:
>98% (SDS-PAGE)
Recombinant Protein Sequence:
Thr32-Gly402
Source:
E. coli
Swissprot #:
P42082