IL-33 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-90-032-10ug | 10ug | £469.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Storage:
Working aliquots are stable for up to 3 months when stored at -20˚C.
Documents
Further Information
Additional Names:
Interleukin-33, IL-1F11, NF-HEV
Application Note:
This recombinant proteins is for research use only.
Background:
Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The 30kDa human IL33 is converted by CASP1 to a 18kDa protein. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1 (MAPK3)/ERK2 (MAPK1), p38 (MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis.
Biological Activity:
Activates human ST2-dependent NF-kappaB pathway.
Buffer:
0.2um-filtered solution in 55mM TRIS-Cl, pH 8.2, containing 150mM NaCl.
Concentration:
1mg/ml
Fusion Tag:
His Tag
NCBI Gene ID #:
90865
NCBI Official Name:
interleukin 33
NCBI Official Symbol:
IL33
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
Q2YEJ5
Protein GI Number:
68565855
Purity:
>90% (SDS-PAGE).
Endotoxin level is less than 1EU/ μg purified protein (LAL test; Lonza).
Endotoxin level is less than 1EU/ μg purified protein (LAL test; Lonza).
Recombinant Protein Sequence:
Thr32-Gly402
Source:
E. coli
Swissprot #:
Q8NI99