Clusterin nuclear form Recombinant Protein
| Code | Size | Price |
|---|
| PSI-90-038-50ug | 50ug | £657.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Storage:
Working aliquots are stable for up to 3 months when stored at -20˚C.
Documents
Further Information
Additional Names:
TRPM-2, Apolipoprotein J, APO-J, CLI, CLU, SGP-2
Application Note:
This recombinant proteins is for research use only.
Background:
Clusterin shares homology with the small heat shock protein family of molecular chaperones. The mature secreted form of the protein is a glycosylated, 80-kDa disulfide-linked heterodimer of alpha and beta subunits (produced by internal cleavage). Clusterin is expressed in virtually all tissues and found in all human fluids. It is involved in numerous physiological processes important for carcinogenesis and tumor growth, including apoptotic cell death, cell cycle regulation, DNA repair, cell adhesion, tissue remodeling, lipid transportation, membrane recycling, and immune system regulation. Clusterin also exists as a nuclear protein. The secreted form of Clusterin has extracellular chaperone and anti-apoptotic activities while the nuclear form acts as a proapoptotic factor.
Buffer:
0.2um-filtered solution in 55mM TRIS-Cl, pH 8.2, containing 150mM NaCl.
Concentration:
1mg/ml
Fusion Tag:
His Tag
NCBI Gene ID #:
1191
NCBI Official Name:
clusterin
NCBI Official Symbol:
CLU
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
P10909
Protein GI Number:
42716297
Purity:
>90% (SDS-PAGE).
Endotoxin level is less than 1EU/ μg purified protein (LAL test; Lonza).
Endotoxin level is less than 1EU/ μg purified protein (LAL test; Lonza).
Recombinant Protein Sequence:
Thr32-Gly402
Source:
E. coli
Swissprot #:
P22352