FGF-23 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-90-115-10ug | 10ug | £433.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Storage:
Working aliquots are stable for up to 3 months when stored at -20˚C.
Documents
Further Information
Additional Names:
Fibroblast Growth Factor 23, Tumor-derived Hypophosphatemia-inducing Factor
Application Note:
This recombinant proteins is for research use only.
Background:
FGF-23 (Fibroblast growth factor 23) is a regulator of phosphate homeostasis. It upregulates EGR1 expression in the presence of KLBy. Acts directly on the parathyroid to decrease PTH secretion. Regulates the vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. Defects in FGF-23 are the cause of autosomal dominant hypophosphataemic rickets (ADHR) and of hyperphosphatemic familial tumoral calcinosis (HFTC).
Biological Activity:
Activates ERK and FRS2alpha phosphorylation in Klotho expressing cells.
Buffer:
0.2um-filtered solution in PBS.
Concentration:
1mg/ml
Fusion Tag:
Fc Tag
NCBI Gene ID #:
8074
NCBI Official Name:
fibroblast growth factor 23
NCBI Official Symbol:
FGF23
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
Q9GZV9
Protein GI Number:
10190674
Purity:
>90% (SDS-PAGE).
Endotoxin level is less than 0.1EU/ μg purified protein (LAL test; Lonza).
Endotoxin level is less than 0.1EU/ μg purified protein (LAL test; Lonza).
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
Q9NSA1