NMNAT3 highly active Recombinant Protein
| Code | Size | Price |
|---|
| PSI-90-356-10ug | 10ug | £469.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Storage:
Working aliquots are stable for up to 3 months when stored at -20˚C.
Documents
Further Information
Additional Names:
Nicotinamide Mononucleotide Adenylyltransferase 3, NMN Adenylyltransferase 3, NaMN Adenylyltransferase 3, EC 2.7.7.18, EC 2.7.7.1
Application Note:
This recombinant proteins is for research use only.
Background:
Mitochondrial NMNAT isoform. Catalyzes the formation of NAD+ from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form of nicotinic acid mononucleotide (NAMN) as substrate with the same efficiency. Can use tiazofurin monophosphate as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i. e. the pyrophosphorolytic cleavage of NAD+. For the pyrophosphorolytic activity, mitochondrial NMNAT isoform can use NAD(+), NADH, NAAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP+, NADPH and NAADP+. Protects against axonal degeneration following injury.
Biological Activity:
>2U/mg protein. One unit is defined as the amount of enzyme that synthesizes 1umol of NAD+ per min.
Buffer:
In 50mM TRIS-HCl, pH 8.0, containing 300mM sodium chloride, 1mM DTT and 10% glycerol.
Concentration:
1mg/ml
Fusion Tag:
His Tag
NCBI Gene ID #:
349565
NCBI Official Name:
nicotinamide nucleotide adenylyltransferase 3
NCBI Official Symbol:
NMNAT3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
Q96T66
Protein GI Number:
30039706
Purity:
>95% (SDS-PAGE)
Recombinant Protein Sequence:
Thr32-Gly402
Source:
E. coli
Swissprot #:
P33681