GCN5 highly active Recombinant Protein
| Code | Size | Price |
|---|
| PSI-90-345-2ug | 2ug | £522.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Shipping:
Dry ice
Storage:
Stable for at least 6 months after receipt when stored at -80˚C.
Documents
Further Information
Additional Names:
GCN5L2, Histone Acetyltransferase GCN5, Histone Acetyltransferase KAT2A, Lysine Acetyltransferase 2A, STAF97
Application Note:
This recombinant proteins is for research use only.
Background:
GCN5 functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. It has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. In case of HIV-1 infection, it is recruited by the viral protein Tat. It regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. GCN5 is a component of the Ada Two-A containing (ATAC) complex, a complex with histone acetyltransferase activity on histones H3 and H4.
Biological Activity:
~200-300ng are required for standard HAT assay.
Buffer:
In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride, 0.2% NP-40, 50mM imidazole and 10% glycerol.
Concentration:
Lot dependent (0.2-0.5mg/ml)
Fusion Tag:
His Tag
NCBI Gene ID #:
2648
NCBI Official Name:
K(lysine) acetyltransferase 2A
NCBI Official Symbol:
KAT2A
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
Q92830
Protein GI Number:
209572743
Purity:
>95% (SDS-PAGE)
Recombinant Protein Sequence:
Thr32-Gly402
Source:
Sf21 cells
Swissprot #:
O88430