HES1 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-90-193-50ug | 50ug | £1,139.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Storage:
Working aliquots are stable for up to 3 months when stored at -20˚C.
Documents
Further Information
Additional Names:
Hairy and Enhancer of Split 1, Transcription Factor HES-1, Class B Basic Helix-loop-helix Protein 39, bHLHb39, Hairy Homolog, Hairy-like Protein, HRY, hHL
Application Note:
This recombinant proteins is for research use only.
Background:
bHLH proteins are essential for neurogenesis, myogenesis, hematopoiesis and sex determination. HES1 (Hairy and Enhancer of Split 1) is a basic Helix-Loop-Helix (bHLH) transcriptional repressor regulated by the Notch pathway and expressed in various tissues. HES1 is well known in development of different tissues, particularly endoderm derived endocrine organs like pancreas and neuroendocrine cells of lung. HES1 controls normal development by regulating proliferation and differentiation and so cell fate. Notch signaling plays both oncogenic and tumor suppressor roles depending on cell type. In contrast to T cell acute lymphoblastic leukemia (ALL), where Notch activation promotes leukemogenesis, induction of Notch signaling in B cell ALL (B-ALL) leads to growth arrest and apoptosis. The Notch target HES1 is sufficient to reproduce this tumor suppressor phenotype in B-ALL by interacting and activating PARP-1 and regulating proapoptotic signals.
Buffer:
0.2um-filtered solution in 55mM TRIS-Cl, pH 8.2, containing 150mM NaCl.
Fusion Tag:
His Tag
NCBI Gene ID #:
3280
NCBI Official Name:
hes family bHLH transcription factor 1
NCBI Official Symbol:
HES1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
Q14469
Protein GI Number:
5031763
Purity:
>90% (SDS-PAGE)
Recombinant Protein Sequence:
Thr32-Gly402
Source:
E. coli
Swissprot #:
P43489