CD27 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-90-391-50ug | 50ug | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Storage:
Stable for at least 1 year after receipt when stored at -20˚C. Working aliquots are stable for up to 3 months when stored at -20˚C.
Documents
Further Information
Additional Names:
T Cell Activation Antigen CD27, T14, TNFRSF7, Tumor Necrosis Factor Receptor Superfamily Member 7, S152
Application Note:
This recombinant proteins is for research use only.
Background:
CD27 (TNFRSF7) is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage and exists as both a dimeric glycoprotein on the cell surface and as a soluble protein in serum. As a T and B cell co-stimulatory molecule, the activity of CD27 is governed by its TNF-like ligand CD70 on lymphocytes and dendritic cells. The CD27-CD70 interaction is required for Th1 generation responses to differentiation signals and long-term maintenance of T cell immunity, and meanwhile, plays a key role in regulating B cell differentiation, activation and immunoglobulin synthesis. The CD27 receptor transduces signals and subsequently leads to the activation of NF-kappaB and MAPK8/JNK, mediated by the adaptor proteins TRAF2 and TRAF5. In addition, the proapoptotic protein SIVA is capable of binding the cytoplasmic tail of CD27 and exerts action in the process of apoptosis.
Buffer:
Lyophilized from 0.2um-filtered solution in 50mM Tris-HCl buffer (pH 8.0) and 500mM NaCl. Reconstitute in sterile water not less than 100 μg/ml, which can then be further diluted to other aqueous solutions.
Fusion Tag:
His Tag
NCBI Gene ID #:
939
NCBI Official Name:
CD27 molecule
NCBI Official Symbol:
CD27
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
AAH12160
Protein GI Number:
15082491
Purity:
>97% (SDS-PAGE).
Endotoxin level is less than 0.1EU/ μg protein (LAL test; Lonza).
Endotoxin level is less than 0.1EU/ μg protein (LAL test; Lonza).
Recombinant Protein Sequence:
Thr32-Gly402
Source:
E. coli
Swissprot #:
Q9JHJ8