Tim-4 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-90-551-100ug | 100ug | £765.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Storage:
Stable for at least 1 year after receipt when stored at -20˚C. Working aliquots are stable for up to 3 months when stored at -20˚C.
Documents
Further Information
Additional Names:
TIM4, TIMD4, T Cell Immunoglobulin and Mucin Domain-containing Protein 4, T Cell Membrane Protein 4
Application Note:
This recombinant proteins is for research use only.
Background:
The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. TIM-4 (T cell; immunoglobulin; Mucin-4), also known as SMUCKLER, is a 60 kDa member of the TIM family of immune regulating proteins. TIM-4 is exclusively expressed on antigen-presenting cells, where it mediates phagocytosis of apoptotic cells and plays an important role in maintaining tolerance. TIM-4 binds specifically to TIM-1 which is also the cellular receptor for the hepatitis A virus, and has been implicated in the development of asthma. Among hematopoietic cells, TIM-1 is expressed on activated B and T cells, preferentially in the Th2 subset of CD4+ T cells. The interaction of TIM-4 with TIM-1 induces costimulatory and hyperproliferative signals in T cells.
Biological Activity:
Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated human T cells.
Buffer:
Lyophilized from 0.2um-filtered solution in PBS. Reconstitute with 100 μl sterile water. Add 1X PBS to the desired protein concentration.
Fusion Tag:
Fc Tag
NCBI Gene ID #:
91937
NCBI Official Name:
T-cell immunoglobulin and mucin domain containing 4
NCBI Official Symbol:
TIMD4
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_612388
Protein GI Number:
226529863
Purity:
>98% (SDS-PAGE).
Endotoxin level is less than 0.06EU/ μg protein (LAL test; Lonza).
Endotoxin level is less than 0.06EU/ μg protein (LAL test; Lonza).
Recombinant Protein Sequence:
Thr32-Gly402
Source:
CHO cells
Swissprot #:
Q6U7R4