IL-21 mutant Recombinant Protein
| Code | Size | Price |
|---|
| PSI-90-510-10ug | 10ug | £433.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Storage:
Stable for at least 1 year after receipt when stored at -20˚C. Working aliquots are stable for up to 3 months when stored at -20˚C.
Documents
Further Information
Additional Names:
Interleukin-21
Application Note:
This recombinant proteins is for research use only.
Background:
Interleukin-21 (IL-21) is a key factor in the transition between innate and adaptive immune responses secreted by activated T cells. The IL-21 receptor (IL-21R) is expressed in lymphoid tissue, in particular by NK, B, T and dendritic cells, macrophages and endothelial cells. Recent evidence suggests that IL-21 plays a supportive role in the proliferation of T and B cells and influences the cytolytic activity of natural killer cells. IL-21 has been shown to up-regulate genes associated with innate immunity and to inhibit the differentiation of naive T helper cells. IL-21 specifically inhibits IFN-gamma production from developing TH1 cells and is preferentially expressed by TH2 cells. Furthermore IL-21 has been identified as a growth and survival factor for human myeloma cells. IL-21/IL-21R interactions have a unique role in sequentially activating both innate and adaptive immune responses against poorly immunogenic tumors, leading to tumor rejection that is perforin dependent but IFN-gamma independent.
Buffer:
Lyophilized from 0.2um-filtered solution in PBS. Reconstitute at 100 μg/ml in sterile PBS.
Fusion Tag:
His Tag
NCBI Gene ID #:
59067
NCBI Official Name:
interleukin 21
NCBI Official Symbol:
IL21
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_068575
Protein GI Number:
11141875
Purity:
>90% (SDS-PAGE).
Endotoxin level is less than 1EU/ μg protein (LAL test; Lonza).
Endotoxin level is less than 1EU/ μg protein (LAL test; Lonza).
Recombinant Protein Sequence:
Thr32-Gly402
Source:
E. coli
Swissprot #:
Q9EPU5