CD137 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-90-410-25ug | 25ug | £597.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Storage:
Stable for at least 1 year after receipt when stored at -20˚C. Working aliquots are stable for up to 3 months when stored at -20˚C.
Documents
Further Information
Additional Names:
Tumor Necrosis Factor Receptor Superfamily Member 9, TNFRSF9, 4-1BB, 4-1BB Ligand Receptor T Cell, Antigen 4-1BB Homolog, T Cell Antigen ILA, CD137 Antigen, CDw137, ILA, MGC2172
Application Note:
This recombinant proteins is for research use only.
Background:
Human CD137 (4-1BB) is a costimulatory molecule of the tumor necrosis factor (TNF) receptor superfamily. The glycoprotein 4-1BB is expressed mainly on activated CD4+ and CD8+ T cells and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. Upon ligand binding, 4-1BB is associated with the tumor receptor-associated factors (TRAF), the adaptor protein and mediates downstream signaling events including the activation of NF-kappaB and cytokine production. 4-1BB signaling either by binding to 4-1BBL or by antibody ligation delivers signals for T cell activation and growth as well as monocyte proliferation and B cell survival, and plays a important role in the amplification of T cell-mediated immune responses. In contrast, it can also enhance activation-induced T cell apoptosis when triggered by engagement of the TCR/CD3 complex. In addition, the 4-1BB/4-1BBL costimulatory pathway has been shown to augment secondary CTL responses to several viruses and increase antitumor immunity. 4-1BB is therefore a promising candidate for immunotherapy of human cancer.
Buffer:
Lyophilized from a concentrated sterile solution containing 50mM Tris-HCl buffer (pH 8.0) and 500mM NaCl. Reconstitute in sterile water not less than 100 μg/ml, which can then be further diluted to other aqueous solutions.
Fusion Tag:
His Tag
NCBI Gene ID #:
3604
NCBI Official Name:
tumor necrosis factor receptor superfamily member 9
NCBI Official Symbol:
TNFRSF9
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
AAH06196
Protein GI Number:
13623201
Purity:
>95% (SDS-PAGE).
Endotoxin level is less than 0.1EU/ μg protein (LAL test; Lonza).
Endotoxin level is less than 0.1EU/ μg protein (LAL test; Lonza).
Recombinant Protein Sequence:
Thr32-Gly402
Source:
E. coli
Swissprot #:
P01588