APRIL H98 multimeric Recombinant Protein
| Code | Size | Price |
|---|
| PSI-90-272-10ug | 10ug | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Storage:
Stable for at least 6 months after receipt when stored at -20˚C.
Documents
Further Information
Additional Names:
ACRP30headless:APRIL, ACRP30headless:CD256, ACRP30headless:TNFSF13, ACRP30headless:A-proliferation-inducing Ligand:
Application Note:
This recombinant proteins is for research use only.
Background:
APRIL is a cytokine that belongs to the TNF superfamily and binds to TACI and BCMA. It is implicated in the regulation of tumor cell growth, is involved in monocyte/macrophage-mediated immunological processes and functions as an important survival factor for plasmablasts and bone marrow plasma cells. MultimericAPRIL™ is a high activity construct in which two trimeric APRIL ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively stimulates proliferation B cell. A basic amino acid sequence (QKQKKQ) close to the N-terminus of APRIL is required for binding to negatively charged sulfated glycosaminoglycan side chains of proteoglycans. Proteoglycans mediate binding of APRIL to tumor cells as well as primary lymphoid cells.
Biological Activity:
Stimulates B cell proliferation.
Buffer:
Contains PBS + 0.5% Trehalose. Reconstitute with 100 μl sterile water.
Concentration:
0.1mg/ml after reconstitution.
Fusion Tag:
DDDDK Tag
NCBI Gene ID #:
8741
NCBI Official Name:
tumor necrosis factor (ligand) superfamily, member 13
NCBI Official Symbol:
TNFSF13
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
O75888
Protein GI Number:
4507599
Purity:
>95% (SDS-PAGE).
Endotoxin level is less than 0.01EU/ μg purified protein (LAL test; Lonza).
Endotoxin level is less than 0.01EU/ μg purified protein (LAL test; Lonza).
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
Q8R460