FLT3 Ligand Recombinant Protein
| Code | Size | Price |
|---|
| PSI-90-300-10ug | 10ug | £505.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Storage:
Stable for at least 6 months after receipt when stored at -20˚C.
Documents
Further Information
Additional Names:
FMS-like Tyrosine Kinase 3 Ligand
Application Note:
This recombinant proteins is for research use only.
Background:
FMS-like tyrosine kinase 3 ligand (FLT3L) acts as a growth factor that increases the number of immune cells (lymphocytes (B cells and T cells)) by activating the hematopoietic progenitors. It binds to FLT3 (CD135) which is found on multipotent progenitor (MPP) and common lymphoid progenitor (CLP) cells in mice. FLT3L induces the mobilization of the hematopoietic progenitors and stem cells in vivo which may help the system to kill cancer cells. FLT3L is crucial for steady-state pDC (plasmacytoid dendritic cells) and cDC (classical dendritic cells) development. Deficiency of FLT3L causes a dramatic decrease in DC numbers, whereas increasing its availability increase in DC numbers.
Biological Activity:
In vitro and in vivo generation of conventional and plasmacytoid dendritic cells (DC).
FLT3L increases in vivo both NK and DC cells numbers in the spleen when mice are injected intraperitoneally with 2 or 10 ug, daily for 10 days (slightly higher effect at 10 ug).
Buffer:
In PBS (sterile).
Concentration:
1mg/ml
Fusion Tag:
Fc Tag
NCBI Gene ID #:
2323
NCBI Official Name:
fms-related tyrosine kinase 3 ligand
NCBI Official Symbol:
FLT3LG
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
P49771
Protein GI Number:
1706818
Purity:
>95% (SDS-PAGE).
Endotoxin level is less than 0.1EU/ μg purified protein (LAL test; Lonza).
Endotoxin level is less than 0.1EU/ μg purified protein (LAL test; Lonza).
Recombinant Protein Sequence:
Thr32-Gly402
Source:
CHO cells
Swissprot #:
P25311