CD40 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-90-269-50ug | 50ug | £541.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Storage:
Stable for at least 6 months after receipt when stored at -20˚C.
Documents
Further Information
Additional Names:
Tumor Necrosis Factor Receptor Superfamily Member 5, TNFRSF5, CD40L Receptor
Application Note:
This recombinant proteins is for research use only.
Background:
CD40 belongs to the TNF-receptor superfamily and is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development and germinal center formation. The interaction of CD40-CD40L is necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells, including non-Hodgkin's and Hodgkin's lymphomas, myeloma and some carcinomas including nasopharynx, bladder, cervix, kidney and ovary.
Biological Activity:
Blocks the binding of CD40L to CD40.
Buffer:
Contains PBS. Reconstitute with 50 μl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
Concentration:
1mg/ml after reconstitution.
Fusion Tag:
Fc Tag
NCBI Gene ID #:
958
NCBI Official Name:
CD40 molecule, TNF receptor superfamily member 5
NCBI Official Symbol:
CD40
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
P25942
Protein GI Number:
4507581
Purity:
>95% (SDS-PAGE).
Endotoxin level is less than 0.01EU/ μg purified protein (LAL test; Lonza).
Endotoxin level is less than 0.01EU/ μg purified protein (LAL test; Lonza).
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
Q9UBH0