Netrin-1 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-90-247-10ug | 10ug | £541.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Storage:
Stable for at least 6 months after receipt when stored at -20˚C.
Documents
Further Information
Additional Names:
NTN1
Application Note:
This recombinant proteins is for research use only.
Background:
Netrin-1 controls guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Netrin-1 is also Involved in tumorigenesis by regulating apoptosis.
Biological Activity:
Induces pluripotent stem cell (iPS) formation and improves reprogramming efficiency of human and mouse somatic cells by inhibiting apoptosis mediated by the receptors DCC or UNC5B (at 150ng /ml). Induces axon outgrowth.
Buffer:
Contains PBS plus protein stabilizer. No BSA included. The protein stabilizer shows no interference with protein activity. Reconstitute with 100 μl sterile distilled water.
Concentration:
0.1mg/ml after reconstitution.
Fusion Tag:
DDDDK Tag
NCBI Gene ID #:
9423
NCBI Official Name:
netrin 1
NCBI Official Symbol:
NTN1
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
O95631
Protein GI Number:
148613884
Purity:
>95% (SDS-PAGE).
Endotoxin level is less than 0.01EU/ μg purified protein (LAL test; Lonza).
Endotoxin level is less than 0.01EU/ μg purified protein (LAL test; Lonza).
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P25063