GITRL, Soluble Recombinant Protein
| Code | Size | Price |
|---|
| PSI-90-004-50ug | 50ug | £686.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Mouse
Storage:
Working aliquots are stable for up to 3 months when stored at -20˚C.
Documents
Further Information
Additional Names:
Glucocorticoid-induced TNF Receptor Ligand, AITRL, Activation-inducible TNF-related Ligand, TNFSF18
Application Note:
This recombinant proteins is for research use only.
Background:
GITRL (Glucocorticoid-induced TNF receptor ligand) is expressed on dendritic cells (DC), monocytes, macrophages, B cells, activated T cells, endothelial cells, osteoclasts and various healthy non-lymphoid tissues (e. g. testis). GITRL is constitutively expressed and released as soluble form by solid tumors and various hematopoietic malignancies. GITRL causes differentiation of osteoclasts, activation of macrophages, but also alteration of carcinoma and leukemia cells and influences apoptosis. Binding to GITR is important in regulating T cell proliferation and TCR-mediated apoptosis. GITRL is implicated in development of autoimmune diseases and in the immune response against infectious pathogens and tumors.
Biological Activity:
Induces GITR-mediated NF-kappaB activation in HEK 293 cells.
Buffer:
0.2um-filtered solution in 10mM glycine, pH 10.0.
Concentration:
0.5mg/ml
Fusion Tag:
DDDDK Tag
NCBI Gene ID #:
240873
NCBI Official Name:
tumor necrosis factor (ligand) superfamily, member 18?
NCBI Official Symbol:
Tnfsf18
NCBI Organism:
Mus musculus
Physical State:
Liquid
Protein Accession #:
Q7TS55
Protein GI Number:
81894654
Purity:
>90% (SDS-PAGE).
Endotoxin level is less than 0.1EU/ μg purified protein (LAL test; Lonza).
Endotoxin level is less than 0.1EU/ μg purified protein (LAL test; Lonza).
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
O35608