ANGPTL4 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-90-075-50ug | 50ug | £657.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Mouse
Storage:
Working aliquots are stable for up to 3 months when stored at -20˚C.
Documents
Further Information
Additional Names:
Angiopoietin-like Protein 4, FIAF, Fasting-induced Adipose Factor, HFARP, Hepatic Fibrinogen/Angiopoietin-related Protein
Application Note:
This recombinant proteins is for research use only.
Background:
ANGPTL4 (Angiopoietin-like protein 4) mainly expressed in endothelial cells (hypoxia-induced). Regulates angiogenesis and modulates tumorigenesis and directly regulates lipid, glucose, and energy metabolism. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. ANGPTL4 is a protein consisting of an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain (FLD). Both domains have distinct biological functions. The coiled-coil domain is responsible for the inhibitory effects on lipoprotein lipase (LPL) converting the active form of LPL into an inactive form, and the FLD domain mediates its antiangiogenic functions. The coiled coil and the FLD domains are separated by a short linker that can be cleaved after secretion. ANGPTL4 appears on the cell surface as the full-length form, where it can be released by heparin treatment. ANGPTL4 protein is then proteolytically cleaved by proprotein convertases (PCs), including furin, PC5/6, paired basic amino acid-cleaving enzyme 4, and PC7.
Biological Activity:
Activates ERK phosphorylation in THP-1 cells.
Buffer:
0.2um-filtered solution in PBS.
Concentration:
1mg/ml
Fusion Tag:
DDDDK Tag
NCBI Gene ID #:
57875
NCBI Official Name:
angiopoietin-like 4?
NCBI Official Symbol:
Angptl4
NCBI Organism:
Mus musculus
Physical State:
Liquid
Protein Accession #:
Q9Z1P8
Protein GI Number:
25008127
Purity:
>90% (SDS-PAGE).
Endotoxin level is less than 0.1EU/ μg purified protein (LAL test; Lonza).
Endotoxin level is less than 0.1EU/ μg purified protein (LAL test; Lonza).
Recombinant Protein Sequence:
Thr32-Gly402
Source:
COS-7 cells
Swissprot #:
Q9Y5C1