Cytochrome C Recombinant Protein

Product Code: PSI-92-128

Supplier: ProSci

Code	Size	Price

PSI-92-128-0.05mg

0.05mg

£883.00

Quantity:

Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO

Target Species: Human

Storage:

Store at -20˚C, stable for 6 months after receipt.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Documents

Datasheet

Further Information

Additional Names:

Cytochrome C, CYCS, CYC

Application Note:

This recombinant protein can be used for biological assays. For research use only.

Background:

Cytochrome C (CYCS) is a small heme protein that belongs to the cytochrome c family. It is found loosely associated with the inner membrane of the mitochondrion. Cytochrome C is a highly soluble protein that functions as a central component of the electron transport chain in mitochondria. CYCS transfers electrons between Complexes III (Coenzyme Q - Cyt C reductase) and IV (Cyt C oxidase). CYCS plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of Cytochrome C to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

Buffer:

Supplied as a 0.2 um filtered solution of 20mM Tris, 0.15M NaCl, 20% Glycerol, pH 8.0. It is not recommended to reconstitute to a concentration less than 100 ug/ml.

Fusion Tag:

C-6 His tag

NCBI Gene ID #:

54205

NCBI Official Name:

cytochrome c, somatic

NCBI Official Symbol:

CYCS

NCBI Organism:

Homo sapiens

Physical State:

Liquid

Predicted Molecular Weight:

12.8 kD

Protein Accession #:

P99999

Purity:

Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin level less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.

Recombinant Protein Sequence:

Thr32-Gly402

Source:

E. coli

Swissprot #:

P99999