Fumarylacetoacetase Recombinant Protein

Product Code: PSI-91-668

Supplier: ProSci

Code	Size	Price

PSI-91-668-0.05mg

0.05mg

£838.00

Quantity:

Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO

Target Species: Human

Storage:

Lyophilized protein should be stored at -20˚C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7˚C for 2-7 days.
Aliquots of reconstituted samples are stable at -20˚C for 3 months.

Documents

Datasheet

Further Information

Additional Names:

Fumarylacetoacetase, FAA, Beta-Diketonase, Fumarylacetoacetate Hydrolase, FAH

Application Note:

This recombinant protein can be used for biological assays. For research use only.

Background:

Fumarylacetoacetase belongs to the FAH family. Fumarylacetoacetase is primary expressed in liver and kidney. It exists as a homodimer and catalyzes the hydrolysis of 4-fumarylacetoacetate into fumarate and acetoacetate. Defects in Fumarylacetoacetase cause tyrosinemia type 1, which is congenital metabolism defect characterized by elevated levels of tyrosine in the blood and urine, and hepatorenal manifestations. Typical features include renal tubular injury, self-mutilation, hepatic necrosis, episodic weakness, and seizures.

Buffer:

Lyophilized from a 0.2 um filtered solution of PBS. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.

Fusion Tag:

C-6 His tag

NCBI Gene ID #:

2184

NCBI Official Name:

fumarylacetoacetate hydrolase (fumarylacetoacetase)

NCBI Official Symbol:

FAH

NCBI Organism:

Homo sapiens

Physical State:

Lyophilized

Predicted Molecular Weight:

47.4 kD

Protein Accession #:

P16930

Protein GI Number:

530394832

Purity:

Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin level less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.

Recombinant Protein Sequence:

Thr32-Gly402

Source:

Human Cells

Swissprot #:

P16930