Cyclophilin C Recombinant Protein

ProSci
Product Code: PSI-91-195
Product Group: Recombinant Proteins
Supplier: ProSci
CodeSizePrice
PSI-91-195-0.05mg0.05mg£883.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Target Species: Human
Storage:
Store at -20˚C, stable for 6 months after receipt.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Documents

Further Information

Additional Names:
Peptidyl-Prolyl Cis-Trans Isomerase C, PPIase C, Cyclophilin C, Rotamase C, PPIC, CYPC
Application Note:
This recombinant protein can be used for biological assays. For research use only.
Background:
Cyclophilin C is an enzyme (EC 5.2.1.8) found in both prokaryotes and eukaryotes that interconverts the cis and trans isomers of peptide bonds with the amino acid proline. Proline has an unusually conformationally restrained peptide bond due to its cyclic structure with its side chain bonded to its secondary amine nitrogen. Most amino acids have a strong energetic preference for the trans peptide bond conformation due to steric hindrance, but prolines unusual structure stabilizes the cis form so that both isomers are populated under biologically relevant conditions. Proteins with prolyl isomerase activity include cyclophilin, FKBPs, and parvulin, although larger proteins can also contain prolyl isomerase domains.
Buffer:
Supplied as a 0.2 um filtered solution of 20mM PB, 150mM NaCl, 10% Glycerol, pH 7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml.
Fusion Tag:
N-Trx, 6 His tag
NCBI Gene ID #:
5480
NCBI Official Name:
peptidylprolyl isomerase C
NCBI Official Symbol:
PPIC
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Predicted Molecular Weight:
33.78 kD
Protein Accession #:
P45877
Purity:
Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin level less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
E. coli
Swissprot #:
P45877