HLA-DP/HLA-DR monoclonal antibody, clone Bra-14

Human

Liquid

DPB1|HLA-DP1B

major histocompatibility complex, class II, DP beta 1

3115|3122

HLA-DPB1

Human REH cells.

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Mouse monoclonal antibody raised against native human HLA-DP/HLA-DR.

P04440;P01903

Flow Cytometry (0.5-1 ug/10⁶ cells in 0.1 mL)
Immunofluorescence (0.5-1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.

Reacts with a common epitope of human major histocompatibility (MHC) class II antigens, HLA-DP and HLA-DR. Human MHC class II antigens are transmembrane glycoproteins composed of an alpha chain (36 kDa) and a beta chain (27 kDa). They are expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, and thymic epithelial cells and are also present on activated T lymphocytes. Human MHC class II genes are located in the HLA-D region that encodes at least six and ten chain genes. Three loci, DP, DQ and DR, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T helper cells. They, therefore, have a critical role in the initiation of the immune response. It has been shown that some autoimmune diseases are associated with certain class II alleles.

In 10 mM PBS (0.05% BSA, 0.05% sodium azide).