5-Hydroxydiclofenac
| Code | Size | Price |
|---|
| CDX-H0053-M001 | 1 mg | £121.00 |
Quantity:
| CDX-H0053-M005 | 5 mg | £450.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
+4°C
Documents
Further Information
Alternate Names/Synonyms:
2-[(2,6-Dichlorophenyl)amino]-5-hydroxybenzeneacetic acid; 5-OH-DFN; 5-OH DCF; BRN4199419
Appearance:
Light grey powder.
CAS:
69002-84-2
Class:
9
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07,GHS09
Handling Advice:
Keep cool and dry.Protect from light and moisture.
Hazards:
H302, H315, H319, H335, H410
InChi:
InChI=1S/C14H11Cl2NO3/c15-10-2-1-3-11(16)14(10)17-12-5-4-9(18)6-8(12)7-13(19)20/h1-6,17-18H,7H2,(H,19,20)
InChiKey:
VNQURRWYKFZKJZ-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 69002-84-2. Formula: C14H11Cl2NO3. MW: 312.2. Synthetic. Metabolite of Diclofenac, a nonsteroidal anti-inflammatory compound that functions via inhibiton of cyclooxygenase (COX). Diclofenac undergoes biotransformation not only by glucuronidation, but also by cytochrome P450?mediated oxidation to produce 4'-OH-DFN and 5-OH-DFN, which undergo subsequent oxidation to form highly electrophilic benzoquinone imine intermediates. Compound can be used as analytical reference material.
MDL:
MFCD01672033
Molecular Formula:
C14H11Cl2NO3
Molecular Weight:
312.2
Package Type:
Vial
Precautions:
P273, P280, P301, P312, P330, P337, P313, P391, P501
Product Description:
Metabolite of Diclofenac, a nonsteroidal anti-inflammatory compound that functions via inhibiton of cyclooxygenase (COX). Diclofenac undergoes biotransformation not only by glucuronidation, but also by cytochrome P450?mediated oxidation to produce 4'-OH-DFN and 5-OH-DFN, which undergo subsequent oxidation to form highly electrophilic benzoquinone imine intermediates. Compound can be used as analytical reference material.
Purity:
>97% (HPLC)
Signal word:
Warning
SMILES:
OC1=CC=C(NC2=C(Cl)C=CC=C2Cl)C(CC(O)=O)=C1
Solubility Chemicals:
Soluble in DMSO or acetone.
Source / Host:
Synthetic.
Transportation:
Non-hazardous
UN Nummer:
UN 3077
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
(1) J.R. Kenny, et al.; J. Med. Chem. 47, 2816 (2004) | (2) D.J. Naisbitt, et al.; Toxicol. Lett. 168, 45 (2007) | (3) D. St?lten, et al.; Sci. Total Environ. 405, 310 (2008) | (4) D.J. Waldon, et al.; Chem. Res. Toxicol. 23, 1947 (2010) | (5) J. Surendradoss, et al.; Drug Metab. Disp. 42, 1834 (2014)