Selamectin
| Code | Size | Price |
|---|
| CDX-S0051-M025 | 25 mg | £310.00 |
Quantity:
| CDX-S0051-M100 | 100 mg | £804.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
+20°C
Documents
Further Information
Alternate Names/Synonyms:
Revolution; Stronghold; (5Z)-25-Cyclohexyl-4'-O-de(2,6-dideoxy-3-O-methyl-alp.-L-arabino-hexopyranosyl)-5-demethoxy-25-de(1-methylpropyl)-22,23-dihydro-5-(hydroxyimino)avermectin A1a
Appearance:
Off-white powder.
CAS:
220119-17-5
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Keep cool and dry.Protect from light and moisture.
InChi:
InChI=1S/C43H63NO11/c1-24-11-10-14-30-23-50-40-36(44-48)27(4)19-33(43(30,40)47)41(46)52-32-20-31(16-15-25(2)38(24)53-35-21-34(49-6)37(45)28(5)51-35)54-42(22-32)18-17-26(3)39(55-42)29-12-8-7-9-13-29/h10-11,14-15,19,24,26,28-29,31-35,37-40,45,47-48H,7-9,12-13,16-18,20-23H2,1-6H3/b11-10+,25-15+,30-14+,44-36-/t24?,26-,28-,31+,32-,33-,34?,35-,37-,38-,39-,40?,42+,43+/m0/s1
InChiKey:
AFJYYKSVHJGXSN-HNLAYDFISA-N
Long Description:
Chemical. CAS: 220119-17-5. Formula: C43H63NO11. MW: 770. Synthetic. Avermectin derivative prepared by hydrolysis and oximation of doramectin. Selamectin is a potent nematocide used for the treatment of parasites that acts as agonist of the GABA (gamma-aminobutyric acid) neurotransmitter in nerve cells and also binds to glutamate-gated chloride channels in nerve and muscle cells of invertebrates. In both cases it blocks the transmission of neuronal signals of the parasites, which are either paralyzed and expelled out of the body, or they starve. It also affects the reproduction of some parasites by diminishing oviposition or inducing an abnormal oogenesis. The substance fights both internal and surface parasitic infection. Compound can be used as analytical reference material.
MDL:
MFCD09837837
Molecular Formula:
C43H63NO11
Molecular Weight:
770
Package Type:
Vial
Product Description:
Avermectin derivative prepared by hydrolysis and oximation of doramectin. Selamectin is a potent nematocide used for the treatment of parasites that acts as agonist of the GABA (gamma-aminobutyric acid) neurotransmitter in nerve cells and also binds to glutamate-gated chloride channels in nerve and muscle cells of invertebrates. In both cases it blocks the transmission of neuronal signals of the parasites, which are either paralyzed and expelled out of the body, or they starve. It also affects the reproduction of some parasites by diminishing oviposition or inducing an abnormal oogenesis. The substance fights both internal and surface parasitic infection. Compound can be used as analytical reference material. Antiviral effective against 2019-nCoV
Purity:
>99% (HPLC)
SMILES:
O[C@@H]1[C@@H](OC)C[C@@](O[C@](C(C)/C=C/C=C(CO2)/[C@@](C2/C(C(C)=C3)=NO)(O)[C@]3([H])C4=O)([H])/C(C)=C/C[C@]5([H])C[C@@](O4)([H])C[C@]6(CC[C@H](C)[C@](C7CCCCC7)([H])O6)O5)([H])O[C@H]1C
Solubility Chemicals:
Soluble in DMSO, dichloromethane, ethanol or methanol. Slightly soluble in water.
Source / Host:
Synthetic.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.
References
(1) B.F. Bishop, et al.; Vet. Parasitol. 91, 163 (2000) | (2) R.H. Six, et al.; Vet. Parasitol. 91, 321 (2000) | (3) B.J. Banks, et al.; Bioorg. Med. Chem. 8, 2017 (2000) | (4) J. Griffin, et al.; J. Vet. Pharmacol. Ther. 28, 257 (2005) | (5) M.U. Esatgil, et al.; Pol. J. Vet. Sci. 11, 67 (2008) | (6) M.U. Esatgil, et al.; Pol. J. Vet. Sci. 11, 143 (2008) | (7) J. Geyer, et al.; J. Vet. Pharmacol. Ther. 32, 87 (2009) | (8) A. Melotti, et al.; EMBO Mol. Med. 6, 1263 (2014) | Repurposing of clinically approved drugs for treatment of coronavirus disease 2019 in a 2019-novel coronavirus-related coronavirus model: H.H. Fan, et al.; Chin. Med. J. 133, 1051 (2020)