IL-36gamma (human) Matched Pair Detection Set
| Code | Size | Price |
|---|
| AG-46B-0010-KI01 | 1 Set | £570.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Application: Enzyme-Linked Immunosorbent Assay (ELISA)
Storage:
Short Term: 4°C Long Term: -20°C
Further Information
Alternate Names/Synonyms:
Interleukin-36gamma Interleukin-1 Family Member 9; IL-1F9
Assay Type:
Sandwich
Detection Type:
Colorimetric
EClass:
32160000
Handling Advice:
Avoid freeze/thaw cycles.
Kit Contains:
1 vial standard protein (100ng) (lyophilized) [STD] | 1 vial coating antibody (120µl) [COAT] | 1 vial detection antibody (20µl) [DET] | 1 vial streptavidin-HRP (10µg) (lyophilized) [STREP]
Long Description:
Matched Pair Detection Set. Detects human IL-36gamma in cell culture supernatant. Colorimetric assay. Sample Type: Cell Culture Supernatant. Range: 3.9 to 250pg/ml. Sensitivity: 1pg/ml. IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination.
Package Type:
Box
Product Description:
IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination.
Range:
3.9 to 250pg/ml
Sample Type:
Cell Culture Supernatant
Sensitivity:
1pg/ml
Specificity:
Detects human IL-36gamma in cell culture supernatant.
Transportation:
Non-hazardous
UNSPSC Category:
ELISA Kits
UNSPSC Number:
41116126
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.
References
Macrophage Phenotypes in Lung Fibrosis: C.K. Koss; Diss. Univ. Konstanz (2021)